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Dishevelled proteíny
Subject h. Dishevelled proteíny Subject h. Dishevelled Proteins Entry terms DVL1 proteín
DVL2 proteín
DVL3 proteínScope note in English A family of proteins that are key components of the WNT SIGNALING PATHWAY, where they function downstream of FRIZZLED RECEPTORS. They contain an N-terminal dishevelled-AXIN PROTEIN (DIX) domain, which mediates oligomerization; a central PDZ DOMAIN which binds to the frizzled receptor; and a C-terminal DEP domain which facilitates binding to the CELL MEMBRANE. Dishevelled proteins have important functions in CELL DIFFERENTIATION and establishing CELL POLARITY. 
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