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proteín komplementačnej skupiny N Fanconiho anémie

  1. Subject h.proteín komplementačnej skupiny N Fanconiho anémie
    Subject h.Fanconi Anemia Complementation Group N Protein
    Entry termsFANCN proteín
    PALB2 proteín
    partner a lokalizátor BRCA2 proteínu
    Scope note in EnglishA Fanconi anemia complementation group protein that contains an N-terminal DNA-binding region and seven, C-terminal, WD REPEATS. It is an essential factor in HOMOLOGOUS RECOMBINATION DNA REPAIR through its interactions with BRCA2 PROTEIN; RAD51 RECOMBINASE; and BRCA1 PROTEIN. It functions as a molecular scaffold to localize and stabilize these proteins at homologous recombination sites. Mutations in the PALB2 gene are associated with FANCONI ANEMIA complementation group N; type 3 PANCREATIC NEOPLASMS; and susceptibility to BREAST CANCER.
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