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cilastatín

  1. Subject h.cilastatín
    Subject h.Cilastatin
    Scope note in EnglishA renal dehydropeptidase-I and leukotriene D4 dipeptidase inhibitor. Since the antibiotic, IMIPENEM, is hydrolyzed by dehydropeptidase-I, which resides in the brush border of the renal tubule, cilastatin is administered with imipenem to increase its effectiveness. The drug also inhibits the metabolism of leukotriene D4 to leukotriene E4.
    Pharmacology effect inhibítory proteáz
    Pharmacology effect Protease Inhibitors
    Links (2) - ARTICLES
    (4) - BOOKS
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