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proteíny onkogénové v-erbA

  1. Subject h.proteíny onkogénové v-erbA
    Subject h.Oncogene Proteins v-erbA
    English X referenceserbA Oncogene Proteins
    v-erbA Proteins
    Scope note in EnglishTransforming proteins encoded by erbA oncogenes from the avian erythroblastosis virus. They are truncated versions of c-erbA, the thyroid hormone receptor (RECEPTORS, THYROID HORMONE) that have retained both the DNA-binding and hormone-binding domains. Mutations in the hormone-binding domains abolish the transcriptional activation function. v-erbA acts as a dominant repressor of c-erbA, inducing transformation by disinhibiting proliferation.
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