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metyléntetrahydrofolátdehydrogenáza (NADP)

  1. Record numberd008754
    Date06.06.2025
    TypeM - MESH
    Topical termmetyléntetrahydrofolátdehydrogenáza (NADP)
    Other termEnglish (Pseudonym) Methylenetetrahydrofolate Dehydrogenase (NADP+)
    Slovak (Pseudonym) metyléntetrahydrofolátdehydrogenáza (NADP+)
    See also(Later heading) formiát-tetrahydrofolátligáza
    (Skutočné meno) formiát-tetrahydrofolátligáza
    (Skutočné meno) metenyltetrahydrofolátcyklohydroláza
    (Later heading) metenyltetrahydrofolátcyklohydroláza
    UDCD08.811.682.662.253
    NoteAn NADP-dependent oxidoreductase that catalyses the conversion of 5,10-methyleneterahydrofolate to 5,10-methenyl-tetrahydrofolate. In higher eukaryotes a trifunctional enzyme exists with additional METHENYLTETRAHYDROFOLATE CYCLOHYDROLASE and FORMATE-TETRAHYDROFOLATE LIGASE activity. The enzyme plays an important role in the synthesis of 5-methyltetrahydrofolate, the methyl donor for the VITAMIN B12-dependent remethylation of HOMOCYSTEINE to METHIONINE via METHIONINE SYNTHETASE.
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