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faktor XIIa

  1. Record numberd015956
    Date06.06.2025
    TypeM - MESH
    Topical termfaktor XIIa
    Other termEnglish (Pseudonym) Coagulation Factor XIIa
    English (Pseudonym) Factor XII, Activated
    Slovak (Pseudonym) faktor koagulačný XIIa
    Slovak (Pseudonym) faktor XII, aktivovaný
    See also(Skutočné meno) koagulanciá
    UDCD08.811.277.656.300.760.324D08.811.277.656.959.350.324D12.776.124.125.450.324D23.119.450.324
    NoteActivated form of factor XII. In the initial event in the intrinsic pathway of blood coagulation, kallikrein (with cofactor HIGH MOLECULAR WEIGHT KININOGEN) cleaves factor XII to XIIa. Factor XIIa is then further cleaved by kallikrein, plasmin, and trypsin to yield smaller factor XII fragments (Hageman-Factor fragments). These fragments increase the activity of prekallikrein to kallikrein but decrease the procoagulant activity of factor XII.
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