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antineoplastiká alkylačné

  1. Record numberd018906
    Date06.06.2025
    TypeM
    Topical termantineoplastiká alkylačné
    Other termEnglish (Pseudonym) Alkylating Agents, Antineoplastic
    Slovak (Pseudonym) látky antineoplastické alkylačné
    Slovak (Pseudonym) látky protinádorové alkylačné
    UDCD27.505.519.124.035D27.505.954.248.150D27.888.569.035.035
    NoteA class of drugs that differs from other alkylating agents used clinically in that they are monofunctional and thus unable to cross-link cellular macromolecules. Among their common properties are a requirement for metabolic activation to intermediates with antitumor efficacy and the presence in their chemical structures of N-methyl groups, that after metabolism, can covalently modify cellular DNA. The precise mechanisms by which each of these drugs acts to kill tumor cells are not completely understood. (From AMA, Drug Evaluations Annual, 1994, p2026)
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