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proteín cytokínovej signalizácie 3, supresorový

  1. Subject h.proteín cytokínovej signalizácie 3, supresorový
    Subject h.Suppressor of Cytokine Signaling 3 Protein
    Entry termsSOCS3 proteín
    supresor cytokínovej signalizácie 3
    Scope note in EnglishA suppressor of cytokine signaling protein that consists of an N-terminal kinase-inhibitory region, a central SH2 DOMAIN, a characteristic C-terminal SOCS box (a 40-amino acid motif, which functions to recruit E3 UBIQUITIN-PROTEIN LIGASE COMPLEXES). SOCS3 inhibits cytokine signaling by binding to RECEPTOR PROTEIN-TYROSINE KINASES as well as CYTOKINE RECEPTOR GP130; ERYTHROPOIETIN RECEPTORS; INSULIN RECEPTOR; and the LEPTIN RECEPTOR. Its functions include suppression of ERYTHROPOIESIS in the fetal liver.
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