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antigén AC133

Subject h.	antigén AC133
Subject h.	AC133 Antigen
Entry terms	antigén AC133-1 antigén AC133-2 antigén AC141 antigén CD133 fudenín PROML1 prominín prominín-1
Scope note in English	A member of the prominin family, AC133 Antigen is a 5-transmembrane antigen occurring as several isoforms produced by alternative splicing which are processed into mature forms. In humans, it is expressed as a subset of CD34 (bright) human hematopoietic stem cells and CD34 positive leukemias. Functionally, it is associated with roles in cell differentiation, proliferation, and apoptosis. Specifically, it regulates the organization of apical plasma membrane in epithelial cells, disk morphogenesis during early retinal development, MAPK and Akt signaling pathways, and in cholesterol metabolism.
See also reference (FX) in Slovak	reakcie antigén-protilátka
See also reference (FX) in English	Antigen-Antibody Reactions
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Number of the records: 1