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TWEAK cytokínový
Subject h. TWEAK cytokínový Subject h. Cytokine TWEAK Entry terms Apo3 ligand
TNF-príbuzný slabý induktor apoptózy
TWEAK cytokín
ligandy superrodiny faktorov nádorovej nekrózy, člen 12Scope note in English A proteolytically-cleaved membrane glycoprotein and member of the TNF superfamily that is highly expressed in a variety of tissues including heart, pancreas, brain, and peripheral blood lymphocytes. The secreted extracellular form is a weak inducer of APOPTOSIS for some cell types and a ligand for the FN14 RECEPTOR. It mediates activation of NF-KAPPA-B and promotes ANGIOGENESIS and proliferation of ENDOTHELIAL CELLS, as well as expression of cytokines involved in INFLAMMATION. 
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