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toxín diftérie

  1. Subject h.toxín diftérie
    Subject h.Diphtheria Toxin
    Entry termstoxín záškrtu
    toxín Corynebacterium diphtheriae
    English X referencesCorynebacterium Diphtheriae Toxin
    Scope note in EnglishAn ADP-ribosylating polypeptide produced by CORYNEBACTERIUM DIPHTHERIAE that causes the signs and symptoms of DIPHTHERIA. It can be broken into two unequal domains: the smaller, catalytic A domain is the lethal moiety and contains MONO(ADP-RIBOSE) TRANSFERASES which transfers ADP RIBOSE to PEPTIDE ELONGATION FACTOR 2 thereby inhibiting protein synthesis; and the larger B domain that is needed for entry into cells.
    Pharmacology effect jedy
    Pharmacology effect Poisons
    See also reference (FX) in Slovak toxoid difterický
    See also reference (FX) in English Diphtheria Toxoid
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    (2) - MeSH descriptor
    (1) - CiBaMed
    (1) - BOOKS
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