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tetrahydrofolátdehydrogenáza

  1. Subject h.tetrahydrofolátdehydrogenáza
    Subject h.Tetrahydrofolate Dehydrogenase
    Entry termsdihydrofolátdehydrogenáza
    dihydrofolátreduktáza
    reduktáza kyseliny listovej
    English X referencesDihydrofolate Dehydrogenase
    Dihydrofolate Reductase
    Folic Acid Reductase
    Scope note in EnglishAn enzyme of the oxidoreductase class that catalyzes the reaction 7,8-dihyrofolate and NADPH to yield 5,6,7,8-tetrahydrofolate and NADPH+, producing reduced folate for amino acid metabolism, purine ring synthesis, and the formation of deoxythymidine monophosphate. Methotrexate and other folic acid antagonists used as chemotherapeutic drugs act by inhibiting this enzyme. (Dorland, 27th ed) EC 1.5.1.3.
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