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kalcineurín

  1. Subject h.kalcineurín
    Subject h.Calcineurin
    Entry termskalcineurín A
    kalcineurín B
    proteínfosfatáza-2B
    fosfatáza proteínová 2B
    English X referencesCalcineurin A
    Calcineurin B
    Protein Phosphatase-2B
    Scope note in EnglishA CALCIUM and CALMODULIN-dependent serine/threonine protein phosphatase that is composed of the calcineurin A catalytic subunit and the calcineurin B regulatory subunit. Calcineurin has been shown to dephosphorylate a number of phosphoproteins including HISTONES; MYOSIN LIGHT CHAIN; and the regulatory subunits of CAMP-DEPENDENT PROTEIN KINASES. It is involved in the regulation of signal transduction and is the target of an important class of immunophilin-immunosuppressive drug complexes.
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