MEFV proteín marenostrín proteín stredomorskej horúčky proteín asociovaný so stredomorskou horúčkou proteín spojený so stredomorskou horúčkou TRIM20 proteín
Scope note in English
A tripartite motif protein that consists of an N-terminal pyrin domain, a central coiled-coil region and B-box type ZINC FINGER, and C-terminal regions that mediate homotrimerization and interactions with other proteins (the B30.2/SPRY DOMAIN). It is expressed primarily by mature GRANULOCYTES and associates with the cytoskeleton in the perinuclear area as well as AUTOPHAGOSOMES, where it co-ordinates the assembly of AUTOPHAGY-RELATED PROTEINS and degradation of INFLAMMASOME components. It functions in INNATE IMMUNITY and INFLAMMATION; mutations in the Pyrin protein (MEFV) gene are associated with FAMILIAL MEDITERRANEAN FEVER.
See also reference (FX) in Slovak
doména pyrínová
See also reference (FX) in English
Pyrin Domain
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(1) - MeSH descriptor
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openseadragon
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