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proteín cytokínovej signalizácie 1, supresorový

  1. Subject h.proteín cytokínovej signalizácie 1, supresorový
    Subject h.Suppressor of Cytokine Signaling 1 Protein
    Entry termssupresor cytokínovej signalizácie 1
    SOCS1 proteín
    Scope note in EnglishA suppressor of cytokine signaling protein that consists of an N-terminal kinase-inhibitory region, a central SH2 DOMAIN, a characteristic C-terminal SOCS box (a 40-amino acid motif, which functions to recruit E3 UBIQUITIN-PROTEIN LIGASE COMPLEXES). SOCS1 functions as a negative regulator of CYTOKINES that signal through the JANUS KINASES-STAT 3 TRANSCRIPTION FACTOR (JAK/STAT3) pathway by inhibiting the activity of JANUS KINASES.
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