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src homológnu 2 doménu obsahujúci transformačný proteín 1

  1. Subject h.src homológnu 2 doménu obsahujúci transformačný proteín 1
    Subject h.Src Homology 2 Domain-Containing, Transforming Protein 1
    Entry termsSHC transformačný proteín 1
    SHC1 proteín
    SHC (src homológnu 2 doménu obsahujúci) transformujúci proteín 1
    SHC1 (src homológnu 2 doménu obsahujúci) proteín
    ShcA proteín
    Scope note in EnglishAn SHC-signaling adaptor protein that transduces PHOSPHOTYROSINE-dependent signals downstream of RECEPTOR PROTEIN-TYROSINE KINASES and non-receptor tyrosine kinases. It is required for TGF-BETA-induced CELL MIGRATION; NEOLPASM INVASION; and METASTASIS of BREAST NEOPLASMS; its SH2 DOMAIN is essential for tumor survival. It also functions in signaling downstream of ANGIOPOIETIN RECEPTOR TIE-2, regulating the migration of ENDOTHELIAL CELLS; and PHYSIOLOGIC NEOVASCULARIZATION.
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Number of the records: 1  

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