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kelch-podobný s ECH asociovaný proteín 1
Subject h. kelch-podobný s ECH asociovaný proteín 1 Subject h. Kelch-Like ECH-Associated Protein 1 Entry terms KEAP-1 proteín
KEAP1 proteínScope note in English An adaptor protein characterized by an N-terminal BTB-POZ DOMAIN and six KELCH REPEATS that functions as a substrate for the E3 UBIQUITIN LIGASE complex. It negatively-regulates NF-E2-RELATED FACTOR 2 by targeting it for ubiquitination and degradation by the PROTEASOME. It also represses genes regulated by ANTIOXIDANT RESPONSE ELEMENTS. 
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