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ADAM17 proteín

  1. Subject h.ADAM17 proteín
    Subject h.ADAM17 Protein
    Entry termsdisintegrín a metaloproteinázovú doménu obsahujúci proteín 17
    ADAM-17 proteín
    CD156b antigén
    TACA (enzým)
    TACE (enzým)
    TNF-alfa konvertáza
    TNF-alfa konvertujúci enzým
    tumor nekrotizujúci faktor alfa konvertáza
    Scope note in EnglishA disintegrin and metalloproteinase domain-containing protein that cleaves the membrane-bound precursor of TUMOR NECROSIS FACTOR-ALPHA to its mature form. It cleaves several other CELL SURFACE PROTEINS, including INTERLEUKIN-1 RECEPTOR TYPE II; TRANSFORMING GROWTH FACTOR ALPHA; L-SELECTIN; MUCIN-1; and AMYLOID BETA-PROTEIN PRECURSOR. It can also function as an activator of the Notch signaling pathway by mediating the cleavage of NOTCH RECEPTORS.
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