ATP7B Cu-Binding P Type ATPase ATPase, Cu++ Transporting, beta Polypeptide (Wilson Disease) Copper-Transporting ATPase Copper-Transporting ATPase 1 Copper-Transporting ATPase 2 Copper-Transporting Adenosine Triphosphatases Cu(+)-Transporting ATPases Cu-Transporting ATPases Menkes Disease-Associated Protein Pineal Night-Specific ATPase Wilson Disease Cu-Binding P Type ATPase
Scope note in English
P-type ATPases which transport copper ions across membranes in prokaryotic and eukaryotic cells. They possess a conserved CYSTEINE-HISTIDINE-SERINE (CPx) amino acid motif within their transmembrane helices that functions in cation translocation and catalytic activation, and an N-terminal copper-binding CxxC motif that regulates enzyme activity. They play essential roles in intracellular copper homeostasis through regulating the uptake, efflux and storage of copper ions, and in cuproprotein biosynthesis.
