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proteín Gli3 obsahujúci zinkové prsty
Subject h. proteín Gli3 obsahujúci zinkové prsty Subject h. Zinc Finger Protein Gli3 Entry terms proteín Gli-Kruppel rodiny, člen 3
proteín obsahujúci zinkové prsty, z rodiny onkogénov asociovaných a gliómomScope note in English A zinc finger transcription factor that contains five CYS2-HIS2 ZINC FINGERS and binds to the GLI consensus sequence 5'-GGGTGGTC-3'. The full-length protein functions as a transcriptional activator whereas the truncated C-terminal form functions as a transcriptional repressor of the Sonic Hedgehog (Shh) signaling pathway; a balance between these two forms is critical for limb and digit development. GLI3 also plays a critical role in the differentiation and proliferation of CHONDROCYTES. 
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