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serínproteáza HTRA2

  1. Subject h.serínproteáza HTRA2
    Subject h.High-Temperature Requirement A Serine Peptidase 2
    Entry termsserínpeptidáza HTRA2
    peptidáza serínová HTRA2
    HTRA2 proteáza
    HTRA serínpeptidáza 2
    Omi serínproteáza
    Scope note in EnglishA serine peptidase that contains a C-terminal PDZ domain. It localizes to the mitochondrial membrane and intermembrane space, translocating to the cytoplasm following APOPTOSIS stimuli, such as UV irradiation; it promotes cell death by binding to and inhibiting INHIBITOR OF APOPTOSIS PROTEINS, resulting in an increase in activity of CASPASES. Mutations in the HTRA2 gene are associated with Type 13 PARKINSON DISEASE.
    See also reference (FX) in Slovak PDZ domény
    See also reference (FX) in English PDZ Domains
    Links (1) - MeSH descriptor
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