choroba z depozície monoklonových imunoglobulínov choroba z ukladania monoklonálnych imunoglobulínov AL amyloidóza amyloidóza primárna systémová amyloidóza z ľahkých reťazcov imunoglobulínu amyloidóza primárna amyloidóza primárna systémová
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Monoclonal Immunoglobulin Deposition Disease
Scope note in English
A nonproliferative disorder of PLASMA CELLS characterized by excessive production and misfolding of IMMUNOGLOBULIN LIGHT CHAINS that form insoluble amyloid fibrils (see AMYLOID DEPOSITS) in various tissues. Clinical features include LIVER FAILURE; MULTIPLE MYELOMA; NEPHROTIC SYNDROME; RESTRICTIVE CARDIOMYOPATHY, and neuropathies.
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