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ubikvitín-proteín ligázy Nedd4
Subject h. ubikvitín-proteín ligázy Nedd4 Subject h. Nedd4 Ubiquitin Protein Ligases Entry terms Nedd4 proteíny
ubikvitínligázy Nedd4Scope note in English E3 ubiquitin ligases that consist of four WW DOMAINS. They accept UBIQUITIN from E2 UBIQUITIN-CONJUGATING ENZYME as a thioester via their C-terminal HECT domains and transfer it specifically to the 63rd LYSINE residue (Lys-63) of target proteins. NEDD4 targets include many proteins and receptors with important functions for cell growth and homeostasis such as VEGFR-2; FGFR1 TYROSINE KINASE; and ERBB-4 RECEPTOR. They play a critical role in the internalization of these receptors, their degradation by LYSOSOMES, and also function as part of the ESCRT complex in VIRUS RELEASE. 
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Number of the records: 1