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proteín 28 obsahujúci tripartitný motív

  1. Subject h.proteín 28 obsahujúci tripartitný motív
    Subject h.Tripartite Motif-Containing Protein 28
    Entry termsTRIM28 proteín
    Scope note in EnglishA tripartite motif protein consisting of an N-terminal RING finger, two B-box type ZINC FINGERS, and C-terminal PHD domain. It functions as a transcriptional repressor by associating with Kruppel-association box domain (KRAB domain) transcription factors and has E3-SUMO-ligase activity towards itself and also sumoylates INTERFERON REGULATORY FACTOR-7 to reduce its activity as a transcriptional activator. It can also function as a ubiquitin protein ligase towards TUMOR SUPPRESSOR PROTEIN P53.
    See also reference (FX) in Slovak prsty zinkové, PHD
    RING prstové domény
    See also reference (FX) in English PHD Zinc Fingers
    RING Finger Domains
    Links (2) - MeSH descriptor
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