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leflunomid

  1. Subject h.leflunomid
    Subject h.Leflunomide
    Entry termsArava
    N-(4-trifluórmetyfenyl)-5-metylizoxazol-4-karboxamid
    Scope note in EnglishAn isoxazole derivative that inhibits dihydroorotate dehydrogenase, the fourth enzyme in the pyrimidine biosynthetic pathway. It is used an immunosuppressive agent in the treatment of RHEUMATOID ARTHRITIS and PSORIATIC ARTHRITIS.
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