antibiotiká benanomicínové antibiotiká benanomicínové a pradimicínové benanomicinóny benanomicíny benanomicíny a pradimicíny antibiotiká pradimicínové antibiotiká pradimicínové a benanomicínové polyketidy podobné pradimicínu polyfenoly pradimicínového typu pradimicinóny pradimicíny
English X references
Benanomicin Antibiotics Benanomicin and Pradimicin Antibiotics Benanomicinones Benanomicins Benanomicins and Pradimicins Pradimicin Antibiotics Pradimicin and Benanomicin Antibiotics Pradimicin-Like Polyketides Pradimicin-Type Polyphenols Pradimicinones Pradimicins
Scope note in English
Polycyclic aromatic polyketides with pentacyclic angular dihydrobenzo(a)naphthacenequinone skeletons. Pradimicin- and related benanomicin-type polyphenols are produced by Actinobacteria, e.g., ACTINOMADURA, using type II polyketide synthase involving condensation of one acetyl-CoA and nine malonyl-CoA. Pradimicins and benanomicins have an amino acid (e.g., D-ALANINE) and often a 5-O-sugar and bind to terminal D-mannosides of the cell wall of various fungi, e.g., CANDIDA. In addition to antifungal activity many pradimicins and benanomicins have anti-HIV activities.
