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polyketidy polyéterové

  1. Subject h.polyketidy polyéterové
    Subject h.Polyether Polyketides
    Entry termspolyétery morské rebríkové
    antibiotiká polyéterové
    antibiotiká polyéterové ionofórové
    ionofóry polyéterové
    English X referencesMarine Ladder Polyethers
    Polyether Antibiotics
    Polyether Ionophore Antibiotics
    Polyether Ionophores
    Scope note in EnglishPolycyclic polyketides with distinctive ladder shaped multiple polyether motifs. In STREPTOMYCES polycyclic polyketide backbones are assembled by type I modular polyketide synthases which then are modified by epoxidase and epoxide hydrolase to achieve their stereochemistry. Polyether ionophore antibiotics coordinate alkali metal cations with their multiple oxygen atoms which disturbs sodium/potassium concentration gradient. They are widely used to treat and control COCCIDIOSIS. Structurally related MARINE LADDER POLYETHERS are neurotoxins.
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