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toxín cholerový

Subject h.	toxín cholerový
Subject h.	Cholera Toxin
Entry terms	toxín cholery cholera toxín enterotoxín cholery CT exotoxín cholery cholera exotoxín toxín cholery, podjednotka A toxín cholery, subjednotka A toxín cholery, podjednotka B toxín cholery, subjednotka B toxín cholery A cholera toxín A toxín cholery B cholera toxín B protomér A toxínu cholery protomér A cholerového toxínu protomér B toxínu cholery protomér B cholerového toxínu choleragén choleragenoid procholeragenoid
English X references	Cholera Toxin A Cholera Toxin B Cholera Toxin Protomer A Cholera Toxin Protomer B Cholera Toxin Subunit A Cholera Toxin Subunit B Choleragen Choleragenoid
Scope note in English	An ENTEROTOXIN from VIBRIO CHOLERAE. It consists of two major protomers, the heavy (H) or A subunit and the B protomer which consists of 5 light (L) or B subunits. The catalytic A subunit is proteolytically cleaved into fragments A1 and A2. The A1 fragment is a MONO(ADP-RIBOSE) TRANSFERASE. The B protomer binds cholera toxin to intestinal epithelial cells and facilitates the uptake of the A1 fragment. The A1 catalyzed transfer of ADP-RIBOSE to the alpha subunits of heterotrimeric G PROTEINS activates the production of CYCLIC AMP. Increased levels of cyclic AMP are thought to modulate release of fluid and electrolytes from intestinal crypt cells.
Pharmacology effect	adjuvanciá imunologické jedy
Pharmacology effect	Adjuvants, Immunologic Poisons
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Number of the records: 1