nádory kolorektálne nepolypózne dedičné nádory kolorektálne nepolypózne hereditárne nádory kolorektálne nepolypózne dedičné, typ 1 nádory dedičné kolorektálne bez polypózy, typ 1 Lynchov syndróm Lynchov syndróm I Lynchov familiárny rakovinový syndróm I nádory kolorektálne nepolypózne familiárne nádory familiárne kolorektálne bez polypózy, typ 1 neoplazmy kolorektálne nepolypózne dedičné HNCC HNPCC
English X references
Colon Cancer, Familial Nonpolyposis, Type 1 Colorectal Cancer, Hereditary Nonpolyposis, Type 1 Familial Nonpolyposis Colon Cancer Type 1 Hereditary Nonpolyposis Colorectal Cancer Hereditary Nonpolyposis Colorectal Cancer Type 1 Hereditary Nonpolyposis Colorectal Neoplasms Lynch Syndrome
Scope note in English
A group of autosomal-dominant inherited diseases in which COLON CANCER arises in discrete adenomas. Unlike FAMILIAL POLYPOSIS COLI with hundreds of polyps, hereditary nonpolyposis colorectal neoplasms occur much later, in the fourth and fifth decades. HNPCC has been associated with germline mutations in mismatch repair (MMR) genes. It has been subdivided into Lynch syndrome I or site-specific colonic cancer, and LYNCH SYNDROME II which includes extracolonic cancer.
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