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kernikterus

  1. Subject h.kernikterus
    Subject h.Kernicterus
    Entry termsžltačka jadrová
    ikterus jadrový
    encefalopatia bilirubínová
    encefalopatia hyperbilirubinemická
    English X referencesBilirubin Encephalopathy
    Hyperbilirubinemic Encephalopathy
    Scope note in EnglishA term used pathologically to describe BILIRUBIN staining of the BASAL GANGLIA; BRAIN STEM; and CEREBELLUM and clinically to describe a syndrome associated with HYPERBILIRUBINEMIA. Clinical features include athetosis, MUSCLE SPASTICITY or hypotonia, impaired vertical gaze, and DEAFNESS. Nonconjugated bilirubin enters the brain and acts as a neurotoxin, often in association with conditions that impair the BLOOD-BRAIN BARRIER (e.g., SEPSIS). This condition occurs primarily in neonates (INFANT, NEWBORN), but may rarely occur in adults. (Menkes, Textbook of Child Neurology, 5th ed, p613)
    Links (6) - ARTICLES
    (2) - CiBaMed
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