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metyléntetrahydrofolátdehydrogenáza (NADP)

  1. Subject h.metyléntetrahydrofolátdehydrogenáza (NADP)
    Subject h.Methylenetetrahydrofolate Dehydrogenase (NADP)
    Entry termsmetyléntetrahydrofolátdehydrogenáza (NADP+)
    English X referencesMethylenetetrahydrofolate Dehydrogenase (NADP+)
    Scope note in EnglishAn NADP-dependent oxidoreductase that catalyses the conversion of 5,10-methyleneterahydrofolate to 5,10-methenyl-tetrahydrofolate. In higher eukaryotes a trifunctional enzyme exists with additional METHENYLTETRAHYDROFOLATE CYCLOHYDROLASE and FORMATE-TETRAHYDROFOLATE LIGASE activity. The enzyme plays an important role in the synthesis of 5-methyltetrahydrofolate, the methyl donor for the VITAMIN B12-dependent remethylation of HOMOCYSTEINE to METHIONINE via METHIONINE SYNTHETASE.
    See also reference (FX) in Slovak formiát-tetrahydrofolátligáza
    metenyltetrahydrofolátcyklohydroláza
    See also reference (FX) in English Formate-Tetrahydrofolate Ligase
    Methenyltetrahydrofolate Cyclohydrolase
    Links (5) - ARTICLES
    (2) - MeSH descriptor
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