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25-hydroxyvitamín D3 1-alfa-hydroxyláza

  1. Subject h.25-hydroxyvitamín D3 1-alfa-hydroxyláza
    Subject h.25-Hydroxyvitamin D3 1-alpha-Hydroxylase
    Entry terms25-hydroxycholekalciferol-1-hydroxyláza
    25-hydroxyvitamín D 1-alfa-hydroxyláza
    CYP27B1
    kalcidiol 1-monooxygenáza
    cytochróm P-450 CYP27B1
    English X references25-Hydroxycholecalciferol 1-Hydroxylase
    CYP27B1
    Calcidiol 1-Monooxygenase
    Cytochrome P-450 CYP27B1
    Scope note in EnglishA mitochondrial cytochrome P450 enzyme that catalyzes the 1-alpha-hydroxylation of 25-hydroxyvitamin D3 (also known as 25-hydroxycholecalciferol) in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP27B1 gene, converts 25-hydroxyvitamin D3 to 1-alpha,25-dihydroxyvitamin D3 which is the active form of VITAMIN D in regulating bone growth and calcium metabolism. This enzyme is also active on plant 25-hydroxyvitamin D2 (ergocalciferol).
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