An active neurotoxic metabolite of 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE. The compound reduces dopamine levels, inhibits the biosynthesis of catecholamines, depletes cardiac norepinephrine and inactivates tyrosine hydroxylase. These and other toxic effects lead to cessation of oxidative phosphorylation, ATP depletion, and cell death. The compound, which is related to PARAQUAT, has also been used as an herbicide.
Pharmacology effect
herbicídy
Pharmacology effect
Herbicides
See also reference (FX) in Slovak
otrava MPTP
See also reference (FX) in English
MPTP Poisoning
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(1) - MeSH descriptor
subject heading
Number of the records: 1
openseadragon
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