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antineoplastiká alkylačné

Subject h.	antineoplastiká alkylačné
Subject h.	Antineoplastic Agents, Alkylating
Entry terms	látky antineoplastické alkylačné látky protinádorové alkylačné
English X references	Alkylating Agents, Antineoplastic
Scope note in English	A class of drugs that differs from other alkylating agents used clinically in that they are monofunctional and thus unable to cross-link cellular macromolecules. Among their common properties are a requirement for metabolic activation to intermediates with antitumor efficacy and the presence in their chemical structures of N-methyl groups, that after metabolism, can covalently modify cellular DNA. The precise mechanisms by which each of these drugs acts to kill tumor cells are not completely understood. (From AMA, Drug Evaluations Annual, 1994, p2026)
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