Number of the records: 1

poly(A)-viažuci proteín II

Subject h.	poly(A)-viažuci proteín II
Subject h.	Poly(A)-Binding Protein II
Entry terms	proteín II viažuci poly(A)
Scope note in English	A poly(A) binding protein that is involved in promoting the extension of the poly A tails of MRNA. The protein requires a minimum of ten ADENOSINE nucleotides in order for binding to mRNA. Once bound it works in conjunction with CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR to stimulate the rate of poly A synthesis by POLY A POLYMERASE. Once poly-A tails reach around 250 nucleotides in length poly(A) binding protein II no longer stimulates POLYADENYLATION. Mutations within a GCG repeat region in the gene for poly(A) binding protein II have been shown to cause the disease MUSCULAR DYSTROPHY, OCULOPHARYNGEAL.
See also reference (FX) in Slovak	dystrofia svalová okulofaryngeálna
See also reference (FX) in English	Muscular Dystrophy, Oculopharyngeal
Links	(1) - MeSH descriptor

subject heading

Number of the records: 1