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neuropilín-1

  1. Subject h.neuropilín-1
    Subject h.Neuropilin-1
    Entry termsantigén A5
    proteín NRP1
    proteín Npn-1
    receptor sema III
    semaforín III receptor
    Scope note in EnglishA dimeric cell surface receptor involved in angiogenesis (NEOVASCULARIZATION, PHYSIOLOGICAL) and AXONAL GUIDANCE. Neuropilin-1 is a 140-kDa transmembrane protein that binds CLASS 3 SEMAPHORINS, and several other growth factors. Neuropilin-1 forms complexes with plexins or VEGF RECEPTORS; their binding affinity and specificity are determined by the composition of the neuropilin dimer and the identity of other receptors complexed with it. Neuropilin-1 is expressed in distinct patterns during neural development, complementary to those described for NEUROPILIN-2.
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