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11-beta-hydroxysteroiddehydrogenáza, typ 2
Subject h. 11-beta-hydroxysteroiddehydrogenáza, typ 2 Subject h. 11-beta-Hydroxysteroid Dehydrogenase Type 2 Entry terms 11-beta-hydroxysteroiddehydrogenáza typu 2 Scope note in English An high-affinity, NAD-dependent 11-beta-hydroxysteroid dehydrogenase that acts unidirectionally to catalyze the dehydrogenation of CORTISOL to CORTISONE. It is found predominantly in mineralocorticoid target tissues such as the KIDNEY; COLON; SWEAT GLANDS; and the PLACENTA. Absence of the enzyme leads to a fatal form of childhood hypertension termed, APPARENT MINERALOCORTICOID EXCESS SYNDROME. 
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