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proteín adaptorový Grb2
Subject h. proteín adaptorový Grb2 Subject h. GRB2 Adaptor Protein Entry terms proteín 2 viažuci sa na receptor rastového faktora English X references Growth Factor Receptor-Bound Protein-2 Scope note in English A signal transducing adaptor protein that links extracellular signals to the MAP KINASE SIGNALING SYSTEM. Grb2 associates with activated EPIDERMAL GROWTH FACTOR RECEPTOR and PLATELET-DERIVED GROWTH FACTOR RECEPTORS via its SH2 DOMAIN. It also binds to and translocates the SON OF SEVENLESS PROTEINS through its SH3 DOMAINS to activate PROTO-ONCOGENE PROTEIN P21(RAS). subject heading
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