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proteíny protoonkogénové c-bcr
Subject h. proteíny protoonkogénové c-bcr Subject h. Proto-Oncogene Proteins c-bcr Entry terms proteíny protoonkogénové bcr
proteíny c-bcrEnglish X references bcr Proto-Oncogene Proteins
c-bcr ProteinsScope note in English A serine-threonine kinase that contains a C2 DOMAIN and PLECKSTRIN HOMOLOGY DOMAIN. It also has activity as a GTPASE-ACTIVATING PROTEIN for RAC1 PROTEIN and CDC42 PROTEIN. It functions as a negative regulator of CELL PROLIFERATION and NEOPLASTIC CELL TRANSFORMATION and is commonly fused with cellular abl protein to form BCR-ABL FUSION PROTEINS in PHILADELPHIA CHROMOSOME positive LEUKEMIA patients. 
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