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motív aktivačný imunoreceptorový, založený na tyrozíne
Subject h. motív aktivačný imunoreceptorový, založený na tyrozíne Subject h. Immunoreceptor Tyrosine-Based Activation Motif Scope note in English A conserved AMINO ACID SEQUENCE located in the intracellular domains of a family of transmembrane proteins involved in various IMMUNE RESPONSES. The CONSENSUS SEQUENCE of this motif is YXXL(or I)X(6-8)YXXL(or I) (where X denotes any amino acid). When phosphorylated ITAM motifs provide docking sites for PROTEIN TYROSINE KINASES of the Syk family thus forming signaling complexes which lead to activation of immune responses. 
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