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komplex podporujúci anafázu - cyklozóm
Subject h. komplex podporujúci anafázu - cyklozóm Subject h. Anaphase-Promoting Complex-Cyclosome Entry terms anafázu podporujúci komplex - cyklozóm Scope note in English An E3 ubiquitin ligase primarily involved in regulation of the metaphase-to-anaphase transition during MITOSIS through ubiquitination of specific CELL CYCLE PROTEINS. Enzyme activity is tightly regulated through subunits and cofactors, which modulate activation, inhibition, and substrate specificity. The anaphase-promoting complex, or APC-C, is also involved in tissue differentiation in the PLACENTA, CRYSTALLINE LENS, and SKELETAL MUSCLE, and in regulation of postmitotic NEURONAL PLASTICITY and excitability. 
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Number of the records: 1