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progranulíny

  1. Record numberd000077153
    Date06.06.2025
    TypeM - MESH
    Topical termprogranulíny
    Other termSlovak (Pseudonym) akrogranín
    Slovak (Pseudonym) Acrogranin
    Slovak (Pseudonym) prekurzor granulínu
    Slovak (Pseudonym) proteín prekurzorový granulínový
    Slovak (Pseudonym) faktor rastový, odvodený od PC buniek
    Slovak (Pseudonym) proepitelín
    Slovak (Pseudonym) progranulín
    UDCD06.472.699.682D12.644.276.917D12.776.467.917D12.776.811.703D23.529.917
    NoteCysteine-rich, precursor glycoproteins encoded by the granulin gene (GRN). They contain granulin-repeats separated by linker sequences that are cleaved by a variety of proteases to release the individual GRANULIN PEPTIDES. The mammalian progranulin is composed of a half-granulin repeat followed by 7 granulin repeats. The mammalian GRANULINS are named PARAGRANULIN and granulin 1-7 for their order in the progranulin propeptide. Progranulin has growth-factor like effects and is expressed over a broad range of tissues. Under-expression of progranulin is linked to neurodegenerative diseases including FRONTOTEMPORAL DEMENTIA and NEURONAL CEROID LIPOFUSCINOSIS, while over-expression is linked to metabolic diseases including OBESITY, and INSULIN RESISTANCE.
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