Number of the records: 1  

cilastatín

  1. Record numberd015377
    Date06.06.2025
    TypeM - MESH
    Topical termcilastatín
    See also(Skutočné meno) inhibítory proteáz
    UDCD02.455.426.392.368.533.200D10.251.355.325.200
    NoteA renal dehydropeptidase-I and leukotriene D4 dipeptidase inhibitor. Since the antibiotic, IMIPENEM, is hydrolyzed by dehydropeptidase-I, which resides in the brush border of the renal tubule, cilastatin is administered with imipenem to increase its effectiveness. The drug also inhibits the metabolism of leukotriene D4 to leukotriene E4.
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