Number of the records: 1
proteín komplexu tuberóznej sklerózy 2
SYS d000077005 LBL 00000nx^^^2200181-^^45^^ 005 20240119195324.5 100 $a 20190101asloy0103 ba0 152 $b mesh 250 $a proteín komplexu tuberóznej sklerózy 2 $x AD $x AE $x AG $x AI $x AN $x BI $x BL $x CF $x CH $x CL $x CS $x DE $x DF $x EC $x GE $x HI $x IM $x IP $x ME $x PD $x PH $x PK $x PO $x RE $x SD $x ST $x TO $x TU $x UL $x UR $8 slo 300 1-
$a 2019 (1994) $8 eng 330 1-
$a An intracellular signaling and tumor suppressor protein that forms a complex with TUBEROUS SCLEROSIS COMPLEX 1 PROTEIN (TSC1) and other signaling factors to negatively regulate MTORC1 and affect cell growth and proliferation. It can also function as GTPASE-ACTIVATING PROTEIN (GAP) for RHEB GTPASE to activate mTORC1 independent of its role in the complex. Structurally, it interacts with TSC1 through its N-terminus, which also contains a leucine zipper and coiled-coil region. It also has multiple phosphorylation sites for different cell signaling kinases, a central coiled-coil region, a C-terminal GAP domain and CALMODULIN binding domain. Mutations in the TSC2 gene are associated with TUBEROUS SCLEROSIS. $8 eng 450 $a tuberín $5 e $8 slo 450 $a proteín tuberóznej sklerózy 2 $5 e $8 slo 686 $a D12.644.360.938 686 $a D12.776.476.935 686 $a D12.776.624.776.769 750 $a Tuberous Sclerosis Complex 2 Protein $8 eng 801 -0
$a SK $b BA006 $c 20190310 801 -2
$a SK $b BA006 $c 20190718 980 $x M
Number of the records: 1