Single-chain polypeptides of about 65 amino acids (7 kDa) from LEECHES that have a neutral hydrophobic N terminus, an acidic hydrophilic C terminus, and a compact, hydrophobic core region. Recombinant hirudins lack tyr-63 sulfation and are referred to as 'desulfato-hirudins'. They form a stable non-covalent complex with ALPHA-THROMBIN, thereby abolishing its ability to cleave FIBRINOGEN.
Pharmacology effect
antitrombíny fibrinolytiká
Pharmacology effect
Antithrombins Fibrinolytic Agents
Links
(5) - ARTICLES
(1) - MeSH descriptor
(5) - BOOKS
subject heading
openseadragon
Number of the records: 1
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