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proteíny protoonkogénové c-abl

  1. Subject h.proteíny protoonkogénové c-abl
    Subject h.Proto-Oncogene Proteins c-abl
    Entry termsproteíny protoonkogénové abl
    proteíny c-abl
    English X referencesabl Proto-Oncogene Proteins
    c-abl Proteins
    Scope note in EnglishNon-receptor tyrosine kinases encoded by the C-ABL GENES. They are distributed in both the cytoplasm and the nucleus. c-Abl plays a role in normal HEMATOPOIESIS especially of the myeloid lineage. Oncogenic transformation of c-abl arises when specific N-terminal amino acids are deleted, releasing the kinase from negative regulation.
    See also reference (FX) in Slovak proteíny fúzne, bcr-abl
    See also reference (FX) in English Fusion Proteins, bcr-abl
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    (2) - MeSH descriptor
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