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antineoplastiká alkylačné
Č. záznamu d018906 Dátum 06.06.2025 Typ M - MESH Tematický termín antineoplastiká alkylačné Iný termín Angličtina (Pseudonym) Alkylating Agents, Antineoplastic
Slovenčina (Pseudonym) látky antineoplastické alkylačné
Slovenčina (Pseudonym) látky protinádorové alkylačné
MDT D27.505.519.124.035D27.505.954.248.150D27.888.569.035.035 Poznámka A class of drugs that differs from other alkylating agents used clinically in that they are monofunctional and thus unable to cross-link cellular macromolecules. Among their common properties are a requirement for metabolic activation to intermediates with antitumor efficacy and the presence in their chemical structures of N-methyl groups, that after metabolism, can covalently modify cellular DNA. The precise mechanisms by which each of these drugs acts to kill tumor cells are not completely understood. (From AMA, Drug Evaluations Annual, 1994, p2026) 
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