MEN2a MEN 2 MEN 2a nádory endokrinné mnohopočetné, typ 2a Sippleov syndróm
Angl. X odkazy
MEN 2 MEN 2a Neoplasia, Multiple Endocrine Type 2a Neoplasms, Multiple Endocrine Type 2a Sipple Syndrome
Vysvetľujúca pozn. v angl.
A form of multiple endocrine neoplasia characterized by the presence of medullary carcinoma (CARCINOMA, MEDULLARY) of the THYROID GLAND, and usually with the co-occurrence of PHEOCHROMOCYTOMA, producing CALCITONIN and ADRENALINE, respectively. Less frequently, it can occur with hyperplasia or adenoma of the PARATHYROID GLANDS. This disease is due to gain-of-function mutations of the MEN2 gene on CHROMOSOME 10 (Locus: 10q11.2), also known as the RET proto-oncogene that encodes a RECEPTOR PROTEIN-TYROSINE KINASE. It is an autosomal dominant inherited disease.
Odkazy
(18) - ČLÁNKY
(2) - heslo MeSH
(5) - CiBaMed
(2) - KNIHY
predmetové heslo
openseadragon
Počet záznamov: 1
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