Počet záznamov: 1

proteín komplementačnej skupiny N Fanconiho anémie

Heslo	proteín komplementačnej skupiny N Fanconiho anémie
Heslo anglicky	Fanconi Anemia Complementation Group N Protein
Odkazy	FANCN proteín PALB2 proteín partner a lokalizátor BRCA2 proteínu
Vysvetľujúca pozn. v angl.	A Fanconi anemia complementation group protein that contains an N-terminal DNA-binding region and seven, C-terminal, WD REPEATS. It is an essential factor in HOMOLOGOUS RECOMBINATION DNA REPAIR through its interactions with BRCA2 PROTEIN; RAD51 RECOMBINASE; and BRCA1 PROTEIN. It functions as a molecular scaffold to localize and stabilize these proteins at homologous recombination sites. Mutations in the PALB2 gene are associated with FANCONI ANEMIA complementation group N; type 3 PANCREATIC NEOPLASMS; and susceptibility to BREAST CANCER.
Odkazy	(1) - ČLÁNKY

predmetové heslo

Počet záznamov: 1