fms Oncogene Protein gp120 fms Oncogene Protein gp140 gp120(v-fms) gp140(v-fms) v-fms Protein
Vysvetľujúca pozn. v angl.
Transforming glycoprotein coded by the fms oncogene from the Susan McDonough strain of feline sarcoma virus (SM-FeSV). The oncogene protein v-fms lacks sequences, which, in the highly homologous proto-oncogene protein c-fms (CSF-1 receptor), normally serve to regulate its tyrosine kinase activity. The missing sequences in v-fms mimic the effect of ligand and lead to constitutive cell growth. The protein gp120(v-fms) is post-translationally modified to generate gp140(v-fms).
Odkazy
(1) - heslo MeSH
predmetové heslo
Počet záznamov: 1
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